Regulation of Gene Expression by cGMP-dependent Protein Kinase
نویسندگان
چکیده
منابع مشابه
Regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase
Background Vascular smooth muscle cells (VSMCs) in normal adult blood vessels exhibit a differentiated, "contractile" phenotype, but in atherosclerotic disease and after acute vascular injury, they de-differentiate into a proliferative, "synthetic" phenotype; the latter is characterized by decreased smooth muscle (SM)-specific gene expression and decreased cGMP-dependent protein kinase (PKG) ac...
متن کاملA cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase.
Vascular smooth muscle cells (VSMCs) undergo phenotypic modulation, changing from a differentiated, contractile to a de-differentiated, synthetic phenotype; the change is associated with decreased expression of smooth muscle (SM)-specific genes and loss of cGMP-dependent protein kinase (PKG), but transfection of PKG into de-differentiated VSMCs restores SM-specific gene expression. We show that...
متن کاملRegulation of cGMP-dependent protein kinase expression by soluble guanylyl cyclase in vascular smooth muscle cells.
Vascular smooth muscle cells (VSMC) undergo many phenotypic changes when placed in culture. Several studies have shown that the levels of expression of soluble guanylyl cyclase (sGC) or cGMP-dependent protein kinase (PKG) are altered in cultured VSMC. In this study the mechanisms involved in the coordinated expression of sGC and PKG were examined. Pro-inflammatory cytokines that increase the ex...
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Type I cGMP-dependent protein kinase (PKG I) plays a major role in vascular homeostasis by mediating smooth muscle relaxation in response to nitric oxide, but little is known about the regulation of PKG I expression in smooth muscle cells. We found opposing effects of RhoA and Rac1 on cellular PKG I expression: (i) cell density-dependent changes in PKG I expression varied directly with Rac1 act...
متن کاملcGMP-Dependent Protein Kinase in the Regulation of Cardiovascular Functions
Cyclic GMP-dependent protein kinase (PKG) was discovered in 1970 in lobster muscle (Kuo & Greengard, 1970). It is a serine/threonine protein kinase specifically activated by cyclic guanosine monophosphate (cGMP). PKG is a ubiquitous intracellular second messenger mediating the biological effects of cGMP elevating agents including nitric oxide (NO), natriuretic peptides, and guanylin (an intesti...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.9.4597